In an interdisciplinary team we combine theoretical and experimental approaches to investigate information processing in nervous systems of different animal models. Our goal is to formulate valid theories and testable model hypotheses.
1. Neural Coding: Reliable and efficient information processing in the noisy brain
The nervous systems of animals employ highly efficient strategies to process sensory information, to form behavioral decisions, and to control their motor actions. Insects have limited neuronal resources and are thus particularly interesting to study fundamentals of efficient neural information processing. Specifically we study adaptive and sparse coding in the olfactory pathway of insects using experimental approaches and functional neural network models. In mammals we study the mechanisms and function of cortical variability during sensory and motor representations.
2. Learning and Memory: Behavioral and neural plasticity in insects
Plasticity in the nervous system is of vital importance for all animals. Insects show a wide repertoire of behavior and fundamental learning abilities. We are interested in uncovering the mechanisms that underlie learning, memory formation and decision-making. With our collaborators we design behavioral and electrophysiological experiments in insects. Based on our experimental analyses we parameterize mathematical and computational neuronal network models that mimic nervous system function and behavior of an individual animal to control autonomous robots.
3. Cortical Motor Control: Planning and execution of voluntary movements in primates
The mammalian neocortex performs high-level control of voluntary movements. We are specifically interested in the coordination of motor cortical with proprioceptive sensory areas. While our movements are precise and accurate, cortical activity shows a high variability across movement repetitions. We study the sources, temporal dynamics and functional role of cortical variability. In our approach we analyze in vivo recordings from monkeys and humans during preparation and execution of movements and employ large scale simulations of cortical attractor networks.
4. Neuromorphic Computing: brain like computation with in silico neural networks
We make use of neuromorphic hardware—electronic versions of neurons and synapses on a microchip—to implement spiking neural networks inspired by the sensory processing architecture of the nervous system of insects. Specifically we are interested in using neuromorphic computing for the control of autonomous robots and for the real-time decoding of spiking neurons in the living brain.
What are we offering?
Expertise in computational modeling of neural network function and behavior, analysis of neurophysiological and behavioral data, machine learning and deep learning.
What are we interested in for collaboration?
Behavioral neurophysiology in primates, specifically invasive neurophysiology.
What platforms, analysis tools or facilities do we use and can share?
Discover our homepage here.
To learn more about Prof. Dr. Martin Paul Nawrot, follow him on ORCID and Twitter.
Methods
Theoretical and experimental approaches to investigate information processing in nervous systems of different animal models
Selected publications
- Schmitt, F. J., Rostami, V., & Nawrot, M. P. (2023). Efficient parameter calibration and real-time simulation of large scale spiking neural networks with GeNN and NEST. Frontiers in Neuroinformatics, 10(17), doi: 10.3389/fninf.2023.941696.
- Springer, M., & Nawrot, M. P. (2021). A mechanistic model for reward prediction and extinction learning in the fruit fly. eNeuro, 8(3), doi: 10.1523/ENEURO.0549-20.2021.
- Sakagiannis, P., Jürgensen, A. M., & Nawrot, M. P. (2021). A realistic locomotory model of drosophila larva for behavioral simulations. bioRxiv, 2021-07.
- Rapp, H., & Nawrot, M. P. (2020). A spiking neural program for sensorimotor control during foraging in flying insects. Proceedings of the National Academy of Sciences, 117(45), 28412-28421, doi: 10.1073/pnas.200982111.
- Betkiewicz, R., Lindner, B., & Nawrot, M. P. (2020). Circuit and cellular mechanisms facilitate the transformation from dense to sparse coding in the insect olfactory system. eNeuro, 7(2), doi: 10.1523/ENEURO.0305-18.2020.
- Nashef, A., Rapp, H., & Nawrot, M. P.*, Prut Y* (2018) Area-specific processing of cerebellar-thalamocortical information in primates. Biological Cybernetics 112, 141-152.
