Gründemann Group

Reliable integration of an ever-changing multitude of sensory inputs from the environment is the basis for learning and memory and shapes our behaviours. Our research aims to understand how sensory inputs are represented and computed to elucidate key principals of multisensory integration. To address this question, we combine state of the art circuit neuroscience tools like opto- and pharmacogenetics with single and two-photon imaging techniques to reveal computational frameworks of multisensory integration in deep brain areas and their effects on behaviour and learning in health and disease.

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Methode:

  • Viral tracing
  • Slice electrophysiology
  • Deep brain miniature microscope and two-photon imaging of large neuronal populations in behaving rodents
  • Optogenetics and chemogenetics
  • Computational analysis of neuronal activity and behaviour

5 selected publications

  1. Single cell plasticity and population coding stability in auditory thalamus upon associative learning.Taylor JA, Hasegawa M, Benoit CM, Freire JA, Theodore M, Ganea DA, Innocenti SM, Lu T, Gründemann J.Nat Commun. 2021 Apr 26;12(1):2438. doi: 10.1038/s41467-021-22421-8.PMID: 33903596 Free PMC article.
  2. Amygdala ensembles encode behavioral states.Gründemann J, Bitterman Y, Lu T, Krabbe S, Grewe BF, Schnitzer MJ, Lüthi A.Science. 2019 Apr 19;364(6437):eaav8736. doi: 10.1126/science.aav8736. Epub 2019 Apr 18.PMID: 31000636
  3. LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li JZ, Lüthi A, Schnitzer MJ.Nature. 2017 Mar 30;543(7647):670-675. doi: 10.1038/nature21682. Epub 2017 Mar 22.PMID: 28329757 Free PMC article.
  4. Distributed coding in auditory thalamus and basolateral amygdala upon associative fear learning.Gründemann J.Curr Opin Neurobiol. 2021 Apr;67:183-189. doi: 10.1016/j.conb.2020.11.014. Epub 2020 Dec 26.PMID: 33373858 Review.
  5. Adaptive disinhibitory gating by VIP interneurons permits associative learning.Krabbe S, Paradiso E, d’Aquin S, Bitterman Y, Courtin J, Xu C, Yonehara K, Markovic M, Müller C, Eichlisberger T, Gründemann J, Ferraguti F, Lüthi A.Nat Neurosci. 2019 Nov;22(11):1834-1843. doi: 10.1038/s41593-019-0508-y. Epub 2019 Oct 21.PMID: 31636447