Empowering the Future of Neuroscience

Empowering the Future of Neurosceince

Fink Group

The Cognitive Neuroscience Section uses behavioral, pharmacological and neuromodulatory methods to elucidate pathomechanisms of neurological and neuropsychological deficits, with the aim to develop innovative diagnostic and therapeutic strategies/procedures.

Using functional imaging (PET and MRI), electrophysiology (EEG, MEG), both systemic (neural networks) and molecular (neurotransmission) approaches utilizing mathematical models (such as dynamic causal modelling) are combined, to arrive at a holistic understanding of the development of normal behavior in the healthy brain (across the entire life span) and disturbed behavior in the diseased brain of neurological patients (e.g. stroke-induced deficits and neurorehabilitation, memory deficits in normal aging and dementias, motor and behavioral deficits in Parkinson’s disease).

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  • Neuromodulation (TMS, TDCS, DBS)
  • Imaging (PET, MRI)
  • Electrophysiology (EEG, MEG)
  • Computational Neuroscience (DCM, graph theory)

5 selected publications

  1. Bonkhoff AK, Espinoza FA, Gazula H, Vergara VM, Hensel L, Michely J, Paul T, Rehme A, Volz LJ, Fink GR, Calhoun VD, Grefkes C. Acute ischemic stroke alters the brain’s preference for distinct dynamic connectivity states. Brain, 143:1525-1540, 2020
  2. Richter N, Beckers N, Onur OA, Dietlein M, Tittgemeyer M, Kracht L, Neumaier B, Fink GR, Kukolja J. Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer’s disease. Brain 141 (3): 903 – 915, 2018
  3. Hoenig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur OA, Jessen F, Fliessbach F, Neumaier B, Fink GR, van Eimeren T, Drzezga A. Networks of tau distribution in Alzheimer’s disease. Brain, 141(2): 568-581, 2018
  4. Volz LJ, Rehme AK, Michely J, Nettekoven C, Eickhoff SB, Fink GR, Grefkes C. Shaping Early Reorganization of Neural Networks Promotes Motor Function after Stroke. Cereb Cortex, 26(6):2882-94, 2016
  5. Schuepbach WM et al. Neurostimulation for Parkinson’s disease with early motor complications. N Engl J Med 368(7):610-22, 2013