Tavosanis Group

My lab is interested in the cellular dynamics that support the development and plasticity of the nervous system. We study how neurons establish their complex distinctive dendrite morphologies. For this, in combination with classical genetics, we are pushing in vivo imaging of differentiating neurons to reveal the subcellular transient localization of active molecular cascades. We […]

Schneider Gorup

We investigate extracellular vesicles (EVs) in neurodegenerative diseases. We are especially interested in EV mediated release of toxic, aggregated proteins, such as a-Synuclein, the determinants of their sorting into EVs and the contribution of their release to toxicity and propagation of disease pathology throughout the brain. We also explore physiological functions of EVs in the […]

Poll Group

It is intriguing how tightly-orchestrated neuronal networks fulfil, what we are appreciating as our mind and what ultimately helps us to define our personality. It is one of our most valuable skills that defines mankind, the ability to create new thoughts and learn from experience. From this it becomes clear that diseases of the central […]

Krabbe Group

Internal states, including emotional conditions such as anxiety or stress, as well as physiological need states like hunger or thirst, strongly influence our behaviour. By modulating the contextual perception of external cues that signal potential rewards or threats, emotional and metabolic states can dynamically control the internal valuation system and thereby affect the selection of […]

Isbrandt Group

The focus of Dirk Isbrandt’s research is on the investigation of molecular mechanisms underlying disease-associated changes in cellular excitability using transgenic mouse models. His team specifically investigates the impact of disease-associated mutations on neuronal ion channels, which cause the so-called ion channel diseases („channelopathies“). His research involves the identification and functional characterization of mutations in […]

Gründemann Group

Reliable integration of an ever-changing multitude of sensory inputs from the environment is the basis for learning and memory and shapes our behaviours. Our research aims to understand how sensory inputs are represented and computed to elucidate key principals of multisensory integration. To address this question, we combine state of the art circuit neuroscience tools […]

Fuhrmann Group

My group aims to understand how neurons and innate immune cells in the brain communicate to lay the foundations for cognition and behaviour. We use neurodegenerative and neuropsychiatric disease models to identify new disease relevant mechanisms that may serve for the development of novel therapeutic strategies. Cutting edge in vivo imaging technologies like awake head-fixed […]

Faber Group

Ataxias are rare diseases with a prevalence of < 5 : 100,000. Clinical hallmarks are progressive loss of balance and coordination accompanied by slurred speech. Consequently, people affected by ataxia suffer substantial restrictions of mobility and communicative skills. The cause may be acquired, sporadic, or genetic. In our research we are focussing on Spinocerebellar ataxias […]

Bradke Group

Wie wachsen Nervenzellen während ihrer frühen Entwicklungsphase? Und wie lassen sich diese Vorgänge reaktivieren, damit nach einer Rückenmarksverletzung beschädigte Nervenzellen regenerieren (nachwachsen) können? Mit diesen Fragen befassen sich Frank Bradke und sein Team. Dem Skelett der Zelle, auch „Zytoskelett“ genannt, gilt das besondere Interesse der Forscher. Sie konnten nachweisen, dass eine Manipulation des Zytoskeletts mit […]

Beck Group

Circuit Mechanisms of Behavior In our group, we are interested in understanding how mammalian behaviors arise from the precisely orchestrated activity patterns in neuronal ensembles. We are fascinated with the mechanisms generating behaviourally relevant activity patterns at different scales ranging from single neurons to neuronal networks spanning different brain areas, with a particular focus on […]